Targeted therapy in antiphospholipid syndrome
نویسندگان
چکیده
منابع مشابه
Targeted therapy in antiphospholipid syndrome.
PURPOSE OF REVIEW To review novel therapeutic targets that are currently under investigation to develop safer, targeted therapies for antiphsopholipid antibody (aPL)-mediated clinical manifestations. RECENT FINDINGS Novel therapeutic options potentially available include anti-CD20 monoclonal antibodies and new-generation anticoagulants (such as direct thrombin and anti-Xa inhibitors). Researc...
متن کاملIntravenous immunoglobulin therapy in antiphospholipid syndrome.
Antiphospholipid syndrome (APS) is an autoimmune disorder defined by the occurrence of venous and arterial thromboses and pregnancy morbidity, frequently accompanied by a moderate thrombocytopenia, in the presence of antiphospholipid antibodies. There is both laboratory and clinical evidence for the beneficial role of intravenous immunoglobulin (IVIg) in APS. Data on the use of IVIg in patients...
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A 20-year-old woman was admitted to a Gynecology Hospital in her 6th month of pregnancy for high blood pressure and tonic-clonic seizure. Primary diagnosis was eclampsia, and for that reason she underwent cesarean section. She also had headache on frontal and parietal areas without nausea or vomiting. There was not a focal neurological sign. Rheumatology consultation was requested. Systemic lup...
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North Am 2000;26:215–27. 14 Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull 1997;53:491–508. 15 Elkon KB. Apoptosis in SLE – too little or too much? Review. Clin Exp Rheumatol 1994;12:553–9. 16 Drappa J, Vaishnaw AK, Sullivan KE, Chu JL, Elkon KB. Fas gene-mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmu...
متن کاملAntiphospholipid syndrome
APS can be primary or secondary. Primary antiphospholipid syndrome occurs in the absence of any other related disease. Secondary antiphospholipid syndrome is often associated with systemic lupus erythematosus and less frequently with infections, drugs and other diseases. Serologic markers are antiphospholipid antibodies, lupus anticoagulant and anticardiolipin. In rare cases, APS leads to rapid...
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ژورنال
عنوان ژورنال: Current Opinion in Rheumatology
سال: 2014
ISSN: 1040-8711
DOI: 10.1097/bor.0000000000000051